Developmental origins of childhood overweight: potential public health impact.

TítuloDevelopmental origins of childhood overweight: potential public health impact.
Publication TypeJournal Article
Year of Publication2008
AuthorsGillman MW, Rifas-Shiman SL, Kleinman K, Oken E, Rich-Edwards JW, Taveras EM
JournalObesity (Silver Spring)
Volume16
Issue7
Pagination1651-6
Date Published2008 Jul
ISSN1930-7381
Palavras-chaveAdult, Body Mass Index, Breast Feeding, Child Development, Child, Preschool, Female, Humans, Logistic Models, Male, Massachusetts, Overweight, Pregnancy, Pregnancy Trimesters, Prenatal Exposure Delayed Effects, Prospective Studies, Public Health, Risk Assessment, Risk Factors, Sleep, Smoking, Time Factors, United States, Weight Gain
Abstract

Several modifiable pre- and postnatal determinants of childhood overweight are known, but no one has examined how they influence risk of overweight in combination. We estimated the risk of overweight at age 3 years according to levels of maternal smoking during pregnancy, gestational weight gain, breastfeeding duration, and infant sleep duration. We studied 1,110 mother-child pairs in Project Viva, a prospective prebirth cohort study. The main outcome measure was child overweight (BMI for age and sex >or=95th percentile) at age 3. We ran logistic regression models with all four modifiable risk factors as well as the covariates maternal BMI and education, child race/ethnicity, and household income. From the model, we obtained the estimated probability of overweight for each of the 16 combinations of the four risk factors. During pregnancy, 9.8% of mothers smoked and 50% gained excessive weight. In infancy, 73% mother-child pairs breastfed for <12 m, and 31% of infants slept <12 h/day. Among the 3-year-old children in the cohort, 9.5% were overweight. In the prediction model, the estimated probability of overweight ranged from 0.06 among children exposed to favorable levels of all four risk factors, to 0.29 with adverse levels of all four. Healthful levels of four behaviors during early development predicted much lower probability of overweight at age 3 than adverse levels. Interventions to modify several factors during pregnancy and infancy could have substantial impact on prevention of childhood overweight.

DOI10.1038/oby.2008.260
Alternate JournalObesity (Silver Spring)
Citation Key30
PubMed ID18451768
PubMed Central IDPMC2650814
Grant ListHD 044807 / HD / NICHD NIH HHS / United States
HD 34568 / HD / NICHD NIH HHS / United States
HL 075504 / HL / NHLBI NIH HHS / United States
HL 64925 / HL / NHLBI NIH HHS / United States
HL 68041 / HL / NHLBI NIH HHS / United States
K23 HD044807 / HD / NICHD NIH HHS / United States
K23 HD044807-05 / HD / NICHD NIH HHS / United States
K24 HL068041 / HL / NHLBI NIH HHS / United States
K24 HL068041-06 / HL / NHLBI NIH HHS / United States
P30 DK040561 / DK / NIDDK NIH HHS / United States
P30 DK040561-13 / DK / NIDDK NIH HHS / United States
R01 HD034568 / HD / NICHD NIH HHS / United States
R01 HD034568-07 / HD / NICHD NIH HHS / United States
R01 HL064925 / HL / NHLBI NIH HHS / United States
R01 HL064925-05 / HL / NHLBI NIH HHS / United States
R01 HL075504 / HL / NHLBI NIH HHS / United States
R01 HL075504-04 / HL / NHLBI NIH HHS / United States